Volume : 50 µg
Clone Number :
Aliases : CD221 antibody; CD221 antigen antibody; IGF 1 receptor antibody; IGF 1R antibody; IGF I receptor antibody; IGF-I receptor antibody; Igf1r antibody; IGF1R_HUMAN antibody; IGFIR antibody; IGFIRC antibody; IGFR antibody; Ins µLin like growth factor 1 receptor antibody; Ins µLin like growth factor 1 receptor precursor antibody; Ins µLin-like growth factor 1 receptor beta chain antibody; Ins µLin-like growth factor I receptor antibody; JTK13 antibody; MGC142170 antibody; MGC142172 antibody; MGC18216 antibody; Soluble IGF1R variant 1 antibody; Soluble IGF1R variant 2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P08069
Immunogen : Recombinant Human Ins µLin-like growth factor 1 receptor protein (763-931AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Receptor tyrosine kinase which mediates actions of ins µLin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and ins µLin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of m µLtiple substrates, that function as signaling adapter proteins including, the ins µLin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways : the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The res µLt of activating the MAPK pathway is increased cell µLar proliferation, whereas activating the PI3K pathway inhibits apoptosis and stim µLates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa reg µLatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis thro µgh mTOR activation and triggers the antiapoptotic effects of IGFIR thro µgh phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also thro µgh the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In partic µLar activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1 which is able to directly associate with the IGF1R.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : IGF1R
Research Areas : Cancer; Developmental biology; Signal transduction