AIF1 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : AIF1 also named as G1 IBA1 or daintain/AIF-1 is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1 there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vasc µLar inflammation. AIF1 promotes the proliferation of vasc µLar smooth muscle cells and of T-lymphocytes. It is also as a microglial cell marker.
Immunogen : allograft inflammatory factor 1
Aliases : AIF 1 AIF1 G1 IBA1 IRT 1 Protein G1
Observed MW : 16 kDa
Uniprot ID : P55008
Reactivity : Human, Mouse, Rat
Application : ELISA, WB
Recommended dilution : WB : 1 : 500-1 : 2000
Gene ID : 199
Research Area : Signal Transduction, Metabolism, Cardiovasc µLar, Developmental biology, Neuroscience, Stem Cells, Immunology