MAPK7 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Plays a role in various cell µLar processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 thro µgh a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the reg µLation of p53/TP53 by disrupting the PML-MDM2 interaction.
Immunogen : mitogen-activated protein kinase 7
Aliases : BMK1 ERK5, PRKM7
Observed MW : 70 kDa
Uniprot ID : Q13164
Reactivity : Human, Mouse
Application : ELISA, WB
Recommended dilution : WB : 1 : 500-1 : 2000
Gene ID : 5598
Research Area : Neuroscience, Signal Transduction, Metabolism