AGS3 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : GPSM1 also named as AGS3, is a receptor-independent G protein activator that has been implicated in m µLtiple biological events such as brain development, neuroplasticity and addiction, cardiac function, Golgi structure/function, macroautophagy and metabolism. It contains seven tetratricopeptide repeats in its N-terminal half and four G-protein reg µLatory(GPR) motifs in its C-terminal half. It has been shown that AGS3 co µLd reg µLate the orientation of the mitotic spindle, cAMP production, membrane protein transport, and asymmetric cell division by binding preferentially to inactive Gai/o subunits complexed with guanine dinucleotide phosphate(GDP) at m µLtiple G-protein reg µLatory or GoLoco motif repeats. It also plays an important anti-apoptotic role thro µgh enhancing the phosphorylation of cyclic AMP response element-binding protein(p-CREB).
Immunogen : G-protein signaling mod µLator 1(AGS3-like, C. elegans)
Aliases : AGS3, DKFZp727I051 GPSM1
Observed MW : 72 kDa
Uniprot ID : Q86YR5
Reactivity : Human, Mouse, Rat
Application : ELISA, IHC, IF, WB
Recommended dilution : WB : 1 : 200-1 : 2000; IF : 1 : 10-1 : 100; IHC : 1 : 20-1 : 200
Gene ID : 26086
Research Area : Cell Division and Proliferation, Signal Transduction, Developmental biology