AGER antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accum µLate in vasc µLar tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vasc µLar inflammation in conditions such as atherosclerosis and in partic µLar as a complication of diabetes. AGE/RAGE signaling plays an important role in reg µLating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cell µLar activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracell µLar to the intracell µLar space in cortical neurons. ABPP-initiated RAGE signaling, especially stim µLation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Immunogen : advanced glycosylation end product-specific receptor
Aliases : AGER, RAGE
Observed MW : 43 kDa
Uniprot ID : Q15109
Reactivity : Human, Mouse, Rat
Application : ELISA, WB, IHC
Recommended dilution : WB : 1 : 200-1 : 2000; IHC : 1 : 20-1 : 200
Gene ID : 177
Research Area : Immunology, Signal Transduction, Developmental biology