AGAP2 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : GTPase-activating protein(GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1(GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stim µLate PI3 kinase but may protect cells from apoptosis by stim µLating Akt. It also reg µLates the adapter protein 1(AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Immunogen : ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Aliases : AGAP 2, AGAP2, Centaurin gamma 1 CENTG1 Cnt g1 FLJ16430, GGAP2, KIAA0167, PIKE
Observed MW : 125 kDa
Uniprot ID : Q99490
Reactivity : Human, Mouse, Rat
Application : ELISA, WB, IHC, IF
Recommended dilution : WB : 1 : 500-1 : 5000; IP : 1 : 200-1 : 2000; IHC : 1 : 20-1 : 200; IF : 1 : 20-1 : 200
Gene ID : 116986
Research Area : Signal Transduction