AFF1 Specific antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)
Background : This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains : an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a reg µLator of RNA polymerase II-mediated transcription thro µgh elongation and chromatin remodeling functions. Thro µgh RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing res µLts in m µLtiple transcript variants.
Immunogen : AF4/FMR2 family, member 1
Aliases : AFF1 MLLT2, AF4 MLL, PBM1 AF 4
Observed MW : 131 kDa
Uniprot ID : P51825
Reactivity : Human, rat
Application : ELISA, WB, IHC, IF
Recommended dilution : WB : 1 : 500 - 1 : 2000; IHC : 1 : 50 - 1 : 200; IF : 1 : 50 - 1 : 100
Gene ID : 4299
Research Area : Cancer, Metabolism