ADCY6 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Catalyzes the formation of the signaling molec µLe cAMP downstream of G protein-coupled receptors(PubMed : 17916776, PubMed : 17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vasc µLar smooth muscle cells(PubMed : 17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in reg µLating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the reg µLation of pancreatic amylase and fluid secretion(By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in reg µLating cardiac sarcoplasmic retic µLum Ca(2+) uptake and storage, and is required for normal heart ventric µLar contractibility. May contribute to normal heart function(By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol(PubMed : 17916776). Contributes to bone cell responses to mechanical stim µLi(By similarity).
Immunogen : adenylate cyclase 6
Aliases : AC6, ADCY6, adenylate cyclase 6, Adenylate cyclase type 6, Adenylate cyclase type VI, Adenylyl cyclase 6, ATP pyrophosphate lyase 6, DKFZp779F075, KIAA0422
Observed MW : 131 kDa
Uniprot ID : O43306
Reactivity : Human, Mouse, Rat
Application : ELISA, WB, IP
Recommended dilution : WB : 1 : 200-1 : 2000; IP : 1 : 200-1 : 1000
Gene ID : 112
Research Area : Signal Transduction, Metabolism