ADAR1 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : ADAR1 is also named as ADAR1 DSRAD, G1P1 IFI4. It convert selected adenosine residues into inosine in substrate RNAs containing a relatively short dsRNA region(PMID : 15556947). The human ADAR1 gene specifies two Volume forms of RNA-specific adenosine deaminase, an interferon(IFN) inducible ?150 kDa protein and a constitutively expressed N-terminally truncated ?110 kDa protein, encoded by transcripts with alternative exon 1 structures that initiate from different promoters(PMID : 11111054). It has 5 isoforms produced by alternative promoter usage and alternative splicing. Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria(DSH).ADAR1 can form respective homodimers, and this association is essential for its enzymatic activities(PMID : 17428802).
Immunogen : adenosine deaminase, RNA-specific
Aliases : ADAR, ADAR1 adenosine deaminase, RNA, DRADA, DSH, DSRAD, G1P1 IFI 4, IFI4, Interferon inducible protein 4, K88dsRBP, p136
Observed MW : 110 kDa
Uniprot ID : P55265
Reactivity : Human, Mouse, Rat
Application : ELISA, IHC, IF, WB, IP
Recommended dilution : WB : 1 : 500-1 : 2000; IHC : 1 : 50-1 : 200; IP : 1 : 200-1 : 1000; IF : 1 : 20-1 : 200
Gene ID : 103
Research Area : Neuroscience, Immunology, Metabolism, Epigenetics