ADAM17 Specific antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : The ADAMs(A Disintegrin And Metalloprotease) are m µLtidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor(TNF)-a from its precursor(PMID : 18238782). ADAM17 is also named as CSVP, TACE. The f µLl length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID : 17438092). This antibody is specific to ADAM17.
Immunogen : ADAM metallopeptidase domain 17
Aliases : ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme
Observed MW : 29 kDa
Uniprot ID : P78536
Reactivity : Human
Application : ELISA, WB
Recommended dilution : WB : 1 : 200-1 : 2000; IHC : 1 : 20-1 : 200
Gene ID : 6868
Research Area : Signal Transduction, Metabolism, Cardiovasc µLar, Immunology, Developmental biology, Neuroscience