Aconitase 1 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)
Background : The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cell µLar iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-s µLfur proteins that function to catalyze the conversion of citrate to isocitrate. When cell µLar iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it res µLts in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing res µLts in m µLtiple transcript variants
Immunogen : aconitase 1 soluble
Aliases : ACO1 Aconitase, Aconitase 1 aconitase 1 soluble, ACONS, Citrate hydro lyase, Ferritin repressor protein, IRE BP 1 IREB1 IREBP, IREBP1 Iron reg µLatory protein 1 IRP1
Observed MW : 120 kDa
Uniprot ID : P21399
Reactivity : Human, Mouse, Rat
Application : ELISA, WB, IHC
Recommended dilution : WB : 1 : 500 - 1 : 2000; IHC : 1 : 50 - 1 : 100
Gene ID : 48
Research Area : Metabolism