ACKR1 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : ACKR1 antibody; Atypical chemokine receptor 1 antibody; CCBP1 antibody; CD234 antibody; DARC antibody; Dfy antibody; Duffy antigen/chemokine receptor antibody; duffy blood group antibody; Duffy blood group antigen antibody; Duffy blood group chemokine receptor antibody; DUFFY_HUMAN antibody; FY antibody; Fy glycoprotein antibody; Glycoprotein D antibody; GPD antibody; GpFy antibody; Plasmodium vivax receptor antibody; WBCQ1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q16570
Immunogen : Recombinant Human Atypical chemokine receptor 1 protein (1-63AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, res µLting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11 CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11 GRO, RANTES, MCP-1 TARC and also for the malaria parasites P.vivax and P.knowlesi. May reg µLate chemokine bioavailability and, consequently, leukocyte recruitment thro µgh two distinct mechanisms : when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circ µLating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ACKR1
Research Areas : Cardiovasc µLar; Immunology; Microbiology; Signal transduction