ACER2 Antibody

Volume : 100 µL
Clone Number :
Aliases : ACER2 antibody; ASAH3L antibody; PP11646 antibody; Alkaline ceramidase 2 antibody; AlkCDase 2 antibody; Alkaline CDase 2 antibody; haCER2 antibody; EC 3.5.1.- antibody; EC 3.5.1.23 antibody; Acylsphingosine deacylase 3-like antibody; N-acylsphingosine amidohydrolase 3-like antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q5QJU3
Immunogen : SyntheVolumed peptide derived from internal of Human ASAH3L.
Raised in : Rabbit
Species Reactivity : Human, Mouse
Tested Applications : ELISA, WB; WB : 1 : 500-1 : 3000
Background : Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18 : 1)-, C(20 : 1)-, C(20 : 4)-ceramide > D-erythro-C(16 : 0)-, C(18 : 0), C(20 : 0)-ceramide > D-erythro-C(24 : 1)-ceramide > D-erythro-C(12 : 0)-ceramide, D-erythro-C(14 : 0)-ceramides > D-erythro-C(24 : 0)-ceramide > D-erythro-C(6 : 0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1 by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.

Xu R., FASEB J. 20 : 1813-1825(2006) [PubMed : 16940153].
Wan D.,Proc. Natl. Acad. Sci. U.S.A. 101 : 15724-15729(2004) [PubMed : 15498874].
Humphray S.J., Nature 429 : 369-374(2004) [PubMed : 15164053].
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Conj µgate : Non-conj µgated
Buffer : Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form : liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ACER2
Research Areas : Metabolism;Signal transduction