AGER Antibody Biotin conjugated

Volume : 50 µg
Clone Number :
Aliases : Advanced glycosylation end product-specific receptor antibody; Ager antibody; DAMA 358M23.4 antibody; MGC2235 antibody; MGC22357 antibody; RAGE_HUMAN antibody; Receptor for advanced glycation end products antibody; Receptor for advanced glycosylation end products antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q15109
Immunogen : Recombinant Human Advanced glycosylation end product-specific receptor protein (23-342AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accum µLate in vasc µLar tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vasc µLar inflammation in conditions such as atherosclerosis and in partic µLar as a complication of diabetes. AGE/RAGE signaling plays an important role in reg µLating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cell µLar activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracell µLar to the intracell µLar space in cortical neurons. ABPP-initiated RAGE signaling, especially stim µLation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : AGER
Research Areas : Neuroscience; Cardiovasc µLar