AGRN Antibody FITC conjugated

Volume : 50 µg
Clone Number :
Aliases : AGRIN antibody; Agrin C-terminal 22 kDa fragment antibody; Agrin proteoglycan antibody; AGRIN_HUMAN antibody; Agrn antibody; C22 antibody; C90 antibody; FLJ45064 antibody; OTTHUMP00000044043 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O00468
Immunogen : Recombinant Human Agrin protein (968-1130AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Isoform 1 : heparan s µLfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromusc µLar junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by reg µLating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly reg µLated by alternative splicing, glycan binding and proteolytic processing. Mod µLates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina thro µgh binding laminin via the NtA domain.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : AGRN
Research Areas : Neuroscience,Signal Transduction