CD32 (Fc Gamma RIIa)(FCGR2A/479) , 1mg / mL

This MAb binds most strongly to the IIa isoforms of CD32 (FcRII) , a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis , cytotoxicity , and immunomodulation as well as platelet aggregation. Three genes (A , B , and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing , i. e. , IIa1 , IIa2 , IIb1 , IIb2 , IIb3 and IIc. Monocytes/macrophages , placental trophoblasts and endothelial cells express all isoforms. In addition , the IIb isoform is expressed by B cells , and the IIa isoform by platelets , granulocytes and , weakly , by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.